Naomi Lee

Assistant Professor

professor naomi lee teaches 2 students in a lab on a computer

Northern Arizona University
Department of Chemistry and Biochemistry
Email: Naomi.Lee@nau.edu
Phone: 928- 523-7379
Office: 36-330

Additional information

Dr. Lee’s research focuses on using peptide and protein-based vaccines as platforms to target infectious and chronic diseases. Vaccine platforms derived from self-assembly were exploited in the development of current human papillomavirus (HPV) and hepatitis B (HBV) vaccines comprised virus-like particles (VLPs). VLPs make effective vaccines because their particulate geometry and multivalent structure provoke strong immune responses (28-31). Similar to VLPs, peptides that self-assemble into ordered fibril structures can elicit strong immune responses due to the geometrical and multivalent display of peptide antigens along the fibril.

Lee, N. R.; Bowerman, C. J.; Nilsson, B. L., (2013) Effects of varied sequence pattern on the self-assembly of amphipathic peptides. Biomacromolecules 2013, 14, 3267-3277. PMID: 23952713
Lee, N. R.; Bowerman, C. J.; Nilsson, B. L., (2013) Sequence length determinants for self-assembly of beta-sheet amphipathic peptides. Biopolymers 2013, 100, 738-750. PMID: 23553562

Related articles
Chackerian, B. (2007) Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines 6, 381-390
Rudra, J. S., Tian, Y. F., Jung, J. P., and Collier, J. H. (2010) A self-assembling peptide acting as an immune adjuvant. Proc Natl Acad Sci U S A 107, 622-627

Education

  • Postdoc (NIH-IRACDA), Vaccines, University of New Mexico
  • Postdoc (IRTA), Viral Immunology, NINDS/NIH
  • PhD, Chemistry, University of Rochester
  • MS, Chemistry, University of Rochester
  • B.S. In Chemistry, Colorado State University