Phone: 928- 523-7379
Dr. Lee’s research focuses on using peptide and protein-based vaccines as platforms to target infectious and chronic diseases. Vaccine platforms derived from self-assembly were exploited in the development of current human papillomavirus (HPV) and hepatitis B (HBV) vaccines comprised virus-like particles (VLPs). VLPs make effective vaccines because their particulate geometry and multivalent structure provoke strong immune responses (28-31). Similar to VLPs, peptides that self-assemble into ordered fibril structures can elicit strong immune responses due to the geometrical and multivalent display of peptide antigens along the fibril.
Lee, N. R.; Bowerman, C. J.; Nilsson, B. L., (2013) Effects of varied sequence pattern on the self-assembly of amphipathic peptides. Biomacromolecules 2013, 14, 3267-3277. PMID: 23952713
Lee, N. R.; Bowerman, C. J.; Nilsson, B. L., (2013) Sequence length determinants for self-assembly of beta-sheet amphipathic peptides. Biopolymers 2013, 100, 738-750. PMID: 23553562
Chackerian, B. (2007) Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines 6, 381-390
Rudra, J. S., Tian, Y. F., Jung, J. P., and Collier, J. H. (2010) A self-assembling peptide acting as an immune adjuvant. Proc Natl Acad Sci U S A 107, 622-627